E. Subramanian, L. Govindasamy, S. Renganayaki: Crystal Structure of t-boc-O-benzyl-L-tyrosyl-D-alanyl-L-(O-benzyl)-glutamate : monohydrate

Crystal Research and Technology

Cryst. Res. Technol. 35 (2000) 1221 - Abstract -

E. Subramanian, L. Govindasamy, S. Renganayaki

Department of Crystallography and Biophysics, University of Madras, India

Crystal Structure of t-boc-O-benzyl-L-tyrosyl-D-alanyl-L-(O-benzyl)-glutamate : monohydrate

The crystal structure of a tripeptide, t-boc-O-benzyl-L-tyrosyl-D-alanyl-L-(O-benzyl)-glutamate has been determined by direct methods, and refined by full-matrix least squares procedures to a final R-index of 0.060. The peptide conformation corresponds to a reverse turn – Type II , stabilized by a 4 – 1 N-H...O hydrogen bond, with the amide proton also forming a bifurcated hydrogen bond to an oxygen atom from the C-terminus of a neighbouring molecule.

Keywords: Tripeptide , X-ray structure , reverse turn , water bridge, bifurcated hydrogen bond

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