Growth of calcium oxalate monohydrate on uric acid crystals at sustained supersaturation by C. Bouropoulos, N. Vagenas, P. Klepetsanis, N. Stavropoulos, and N. Bouropoulos

Crystal Research and Technology

Cryst. Res. Technol. 39, 699 (2004) - Abstract -

Growth of calcium oxalate monohydrate on uric acid crystals at sustained supersaturation

C. Bouropoulos, N. Vagenas*, P. Klepetsanis*, N. Stavropoulos, and N. Bouropoulos**

Department of Urology, ‘G. Hatzikosta’, General Hospital, Ioannina, Greece
*Department of Pharmacy, University of Patras, Patras, Greece
**Department of Materials Science, University of Patras, Patras, Greece

Keywords	calcium oxalate, uric acid, urinary stones, constant supersaturation
PACS	81.10.-h
DOI	10.1002/crat.200310241

The effect of uric acid seeds on calcium oxalate formation was studied at pH 4.50 and 37°C using a system providing constant supersaturation with respect to calcium oxalate and saturated in uric acid. In all cases the only solid-phase forming was identified as calcium oxalate monohydrate (COM). Kinetic analysis of the initial rates showed that they were proportional with the relative supersaturation with respect to calcium oxalate monohydrate. The linear dependence of the rate of precipitation of COM on uric acid suggested that growth is mediated through a surface diffusion controlled mechanism.

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