Crystal structure and conformation study of N-methyl-t-3-methyl-r-2, c-6-diphenylpiperidin-4-one thiosemicarbazone by N. Sampath, M. N. Ponnuswamy, and M. Nethaji

Crystal Research and Technology

Cryst. Res. Technol. 41, 192 (2006) - Abstract -

Crystal structure and conformation study of N-methyl-t-3-methyl-r-2, c-6-diphenylpiperidin-4-one thiosemicarbazone

N. Sampath, M. N. Ponnuswamy, and M. Nethaji*

Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai – 600 025, India
*Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore- 560 012, India

Keywords	crystal structure, conformation, hydrogen bonding, piperidine, NMMDPT
PACS	61.66.Hq
DOI	10.1002/crat.200510554

Thiosemicarbazones are having the ability to bind with metal and inhibit the enzyme ribonucleoside diphosphate reductase (RDR), an enzyme which is involved in the synthesis of DNA precursors in the mammalian cells. The title compound N-methyl-t-3-methyl-r-2, c-6-diphenylpiperidin-4-one thiosemicarbazone (NMMDPT), CCDC 218052, was prepared using Mannich reaction and characterized by X-ray diffraction methods.

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