Crystal Research and Technology
Cryst. Res. Technol. 43, 22 (2008) - Abstract -

Growth rate of single acetaminophen crystals in supersaturated aqueous solution under different operating conditions

W. Omar, S. Al-Sayed*, A. Sultan*, and J. Ulrich**

Tafila Technical University, Department of Natural Resources and Chemical Engineering, Tafila, Jordan
*University of Jordan , Chemical Engineering Department, Amman 11942, Jordan
**Martin-Luther-Universität Halle-Wittenberg, Zentrum für Ingenieurwissenschaften, Verfahrenstechnik/ TVT, 06099 Halle, Germany

Keywords growth rate, single crystal, scetaminophen, paracetamol, supersaturation, temperature, pH, crystal elongation
PACS 81.10.Dn
DOI 10.1002/crat.200710995

Single crystal growth experiments were conducted to investigate the growth rate of acetaminophen (paracetamol) crystals under carefully controlled conditions of temperature, supersaturation and pH value. The relative growth rate of the different faces was studied. Growth Rate Dispersion (GRD) was observed by studying the effect of supersaturation and temperature on the growth rate. The growth rate in all directions was found to be temperature dependant. Elongation of the crystals was measured due to the faster growth in the Y- direction and Xa direction compared to in the Xb direction. Dissolution of the crystals was observed at pH values greater than 8.5, and a growth rate retardation was observed when increasing the pH from 5.6, which is the normal value without additions, to higher values in both acidic and basic mediums up to 8.5.




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