Crystal Research and Technology
Cryst. Res. Technol. 43, 229 (2008) - Abstract -

Application of mean-separation-works method to protein crystal nucleation

Christo N. Nanev

Rostislaw Kaischew Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, “akad. G. Bonchev” str. bl. 11 BAS, Bulgaria

Keywords protein crystal nucleation, protein crystal lattice contacts, mean-separation-works, nucleus form and energy barrier for nucleus formation
PACS 87.15.Nn
DOI 10.1002/crat.200711085

Using mean-separation-works method of Stranski and Kaischew calculations of nucleus form and energy barrier for its formation are performed for globular protein crystals. This is done on the basis of a simple model suggested for crystal nucleation of such proteins. The prerequisite for the model is the fact that strict selection of definite sticky patches on protein molecule surface is obligatory for forming crystal lattices. The calculation results are in agreement with experimental data.

Dedicated to centenary of the birthday of Professor Dr. Rostislaw A. Kaischew (29.02.1908 – 18.11.2002).




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